A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). Studies show that the development of pityriasis rosea during pregnancy may cause birth complications, including miscarriage and poor muscle tone and development once the baby is born (neonatal hypotonia). Of the reported cases, 96.7% were secondary to the Pfizer vaccine, with only 1 reported . It may appear on any part of your body, but it usually appears on the trunk (torso), arms and legs. Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. This site needs JavaScript to work properly. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. eCollection 2022. Accessibility Epub 2022 May 31. 8 Types of Rashes That Can Be a Sign of COVID-19 - Health Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1). 2021;184(6):11941195. (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. See this image and copyright information in PMC. Proc (Bayl Univ Med Cent). World J Clin Cases. Clipboard, Search History, and several other advanced features are temporarily unavailable. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. Disclaimer. Keywords: JAAD Case Rep. (2018) 4:8001. It was found on younger COVID-19 patients suffering milder forms of the virus. MeSH Federal government websites often end in .gov or .mil. The exanthem was self-limited in both patients over a period of a month. Unauthorized use of these marks is strictly prohibited. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. FOIA Epub 2022 Jun 21. Herald patch in the right hypochondrium followed by typical oval-shaped secondary plaques, Pityriasis rosea lesions on the upper extremities, MeSH Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. The .gov means its official. official website and that any information you provide is encrypted Would you like email updates of new search results? Accessibility Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations The etiopathogenesis of PR is still unknown, but is frequently associated with episodes of upper respiratory tract infections. Br J Dermatol. PR is a rare cutaneous reaction after mRNA vaccination against SARS-CoV-2. Dermatologic side effects of COVID-19 vaccines range from morbilliform rash and pernio to pityriasis rosea and erythema multiforme. As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. Br J Dermatol. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. Int J Infect Dis. New York City-based dermatologist Macrene Alexiades. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. For instance, the rash sometimes appears only under the arms or on the flanks. doi: 10.1002/jmv.26549, 9. Careers. However, a fungus causes ringworm. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Pityriasis rosea-like Covid-arm Erythema multiforme Erythroderma Psoriasis Others Grover-like eruptions Herpes simplex reactivation: 24 1 17 4 2 2 1 1 20 15 9 5 2 1 1 1 3 3: 21.5 0.9 15 3.5 1.8 1.8 0.9 0.9 In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. Please enable it to take advantage of the complete set of features! You cant spread pityriasis rosea to another person through unprotected sex or skin-to-skin contact. J Formos Med Assoc. An official website of the United States government. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Pityriasis rosea developing after COVID-19 vaccination. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. Borgia F, Li Pomi F, Alessandrello C, Vaccaro M, Pioggia G, Gangemi S. J Dermatol. Epub 2021 Aug 7. Bathe or shower in lukewarm water. Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? I video-chatted with my dermatologist who asked a few questions: Did I have body aches or flu-like symptoms? (2006) 12:1. doi: 10.5070/D380D8301D, 11. Cutaneous Eruptions in the Course of COVID-19 Among Geriatric Patients in a Nursing Home in Poland. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. MeSH 2021;185(2):e34. Six cases of pityriasis rosea following SARS-CoV-2 vaccination with BNT162b2. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. You may be more likely to develop it if youre: In some cases, people with pityriasis rosea report that they had significant or long-term stress before developing a rash. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. I tell my patient to use a gentle non-soap cleanser." 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. J Am Acad Dermatol. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Dos Santos PG, Vieira HCVS, Wietholter V, Gallina JP, Andrade TR, Marinowic DR, Zanirati GG, da Costa JC. Pityriasis rosea often occurs this way, but not always. Zendaya Shows Off Her Short Sunshine Curls. Unable to load your collection due to an error, Unable to load your delegates due to an error. PR also tends to occur in patients between the ages of 10 to 35 that are usually otherwise healthy, Lam says. Parakeratosis with minimal acanthosis and spongiosis of the epidermis. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. They develop in a pattern that resembles sagging Christmas tree branches. Fried foods, including many fast-food items. Epub 2022 Jun 21. JAAD Case Rep 2018; 4: 800801. Pityriasis lichenoides has distinct acute and chronic forms, which are usually distinct . Pityriasis rosea is a rash that usually appears on the torso, upper arms, thighs or neck. (2021) 35:e5468. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Most people with the rash are 10 to 35 years of age. At first, I thought it was a mosquito bite. Pityriasis Rosea Induced by COVID preview & related info | Mendeley Rare Heterogeneous Adverse Events Associated with mRNA-Based COVID-19 Vaccines: A Systematic Review. These findings were consistent with a diagnosis of PR-like eruption. "It looks very different.". The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. -. The Moderna and Pfizer-BioNTech COVID-19 vaccines are the first two COVID-19 vaccines authorized by the Food and Drug Administration for emergency use and already have been given to millions of Americans. Flares of other types of skin conditions [like psoriasis] sometimes have been described as well," says Lam. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Diagnostic and prognostic values of cutaneous manifestations in COVID-19. Disseminated erythematous-papulosquamous lesions, with right laterocervical herald patch (clinical aspect on admission). Epub 2020 Nov 20. The https:// ensures that you are connecting to the Numerous scattered erythematous, Pityriasis rosea. Epub 2021 Apr 7. While unusual, one patient developed pityriasis rosea once a year for five years in a row. Diagnoses: "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. Although the exact pathogenesis of PR is unknown, current evidence suggests that an inflammatory reaction due to a viral trigger may lead to the cutaneous manifestations. The average time between vaccination and rash onset is 10 days, and most patients experience pruritus (70%). Urbina F, Das A, Sudy E. Clinical variants of pityriasis rosea. As King notes, there have been some reported cases of pityriasis rosea occurring in patients after receiving certain vaccines, like the flu shot. Luckily, it's not contagious. Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Also, topical medication with dermatocorticosteroids and emollients was associated. 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. Epub 2022 Jun 26. Clipboard, Search History, and several other advanced features are temporarily unavailable. An official website of the United States government. 2021;35(8):e489e491. sharing sensitive information, make sure youre on a federal Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. -, Mahajan K, Relhan V, Relhan AK, et al. Medicines (Basel). Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. The typical distribution of the rash is on the trunk between the neck and the knees.". doi: 10.1111/ijd.13061. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Would you like email updates of new search results? Pityriasis rosea usually resolves on its own without treatment in most cases, King says, but topical corticosteroids can be used for itchy control if necessary, which is what I used. J Eur Acad Dermatol Venereol 2020;34:e4367. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. Lessons: Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . The .gov means its official. You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). 2022 Sep-Oct;40(5):586-590. doi: 10.1016/j.clindermatol.2022.01.002. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. From grooming sets to self-care gadgets, we've got them covered. She diagnosed it as pityriasis rosea, a benign but frustratingly itchy rash that in her words just happens sometimes. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. Cured meats with nitrates, such as hot dogs. Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. Dermatol Ther. The condition is more prevalent in spring and fall. The .gov means its official. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. Authors Elina Khattab 1 , Eirini Christaki 2 , Constantinos Pitsios 1 Affiliations 1 Medical School, University of Cyprus, Nicosia, Cyprus. Many Americans become infected with them at an early age. If you have a very itchy rash, your healthcare provider may prescribe the following to help relieve your symptoms: There are several over-the-counter products or home remedies that can help stop your rash from itching. "Sometimes it can spread to what we called the proximal extremities, meaning the parts that are closer to the trunk, so the shoulders, upper arms, [and] the thighs," she says. -. Dermoscopy of the lesions showing peripheral collarette scaling, blood Could covid-19 infection cause pityriasis rosea why? According to King, an in-person skin exam is usually enough to make an accurate diagnosis, though a biopsy or blood work may be necessary for some. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). Your Random Rash Could Be Pityriasis Rosea | Allure official website and that any information you provide is encrypted Epub 2020 Jun 29. These strains of the herpes virus arent related to the strains that cause cold sores or genital herpes. 2023 Cond Nast. Clin Dermatol. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. eCollection 2022. "Any type of stress on the body can sometimes [cause them, and] any vaccine, not just the COVID one.". Received: 03 August 2021; Accepted: 17 August 2021; Published: 07 September 2021. The following self-care tips may help relieve the discomfort of pityriasis rosea: Take nonprescription allergy medicine (antihistamines), such as diphenhydramine (Benadryl, others). Disclaimer. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine J Eur Acad Dermatol Venereol. The https:// ensures that you are connecting to the A case of Herpes Zoster Ophtalmicus after third dose of Comirnaty 2021 Sep;35 (9):e546-e548. Unauthorized use of these marks is strictly prohibited. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2020;34:e2123. . At home, she underwent systemic treatment with antihistamines and topical medication with dermatocorticosteroids. Frontiers | Case Report: Pityriasis Rosea-Like Eruption Following COVID Disclaimer. J Investig Dermatol 2005;124:123440. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). doi: 10.1111/jdv.17342. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. The papulovesicular and pityriasis rosea . Shabazz DR. Pityriasis Rosea. . Your Random Rash Could Be Pityriasis Rosea - Yahoo! doi: 10.7759/cureus.22414. KL and KP collated resources. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk. J Med Virol 2021; 93: 18501851. doi: 10.1111/jdv.12942, 13. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. Get many smaller patches or bumps on your skin. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. 8:752443. doi: 10.3389/fmed.2021.752443. doi: 10.1111/jdv.17342. In: Papadakis MA, McPhee SJ, Bernstein J., eds. Disseminated erythematous-papulosquamous lesions, with right. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. (2021). Pityriasis rosea-like eruption revealing COVID-19. Drago F, Ciccarese G, Rebora A, Parodi A. Children often get infected when someone sneezes or kisses them. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Careers. 2022 Aug;35(8):e15601. Int J Infect Dis. and transmitted securely. JAAD Int. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. government site. Pityriasis rosea-like eruptions following vaccination with BNT162b2 eCollection 2022 Feb. Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Microorganisms. All rights reserved. An official website of the United States government. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. Unable to load your collection due to an error, Unable to load your delegates due to an error. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Cureus. Int J Infect Dis. J Eur Acad Dermatol Venereol. Clinical aspect of the lesions after 7days of treatment. 2022 Feb 20;14(2):e22414. The site is secure. A team of researchers . N Engl J Med 2020; 383: 26032615. government site. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. 2021 May;62(2):e333-e334. (No.) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Ramot Y, Nanova K, Faitatziadou SM, Assab DA, Berkun Y, Zlotogorski A. J Dtsch Dermatol Ges. Most of the rare, severe allergic reactions to these vaccines have occurred in people with a history of allergies. -, Broccolo F, Drago F, Careddu AM, et al. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. However, there isnt enough research to determine that stress may cause pityriasis rosea. However, if you scratch your patches, you may break your skin, leading to an infection that can cause pain. (2021) p. e15040. eCollection 2022. FOIA Epub 2022 Oct 17. Appointments 216.444.5725 Appointments & Locations Request an Appointment (2020) 33:e13878. It should clear your body in six to eight weeks. (2017) 5:20311. The most commonly reported features . 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Pityriasis rosea - Diagnosis and treatment - Mayo Clinic 2020 Jul;33(4):e13730. National Library of Medicine This tiny glimpse of her natural texture is thrilling. Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. We do not endorse non-Cleveland Clinic products or services. Epub 2022 Jun 13. 8 PDF Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases D. McMahon, E. Amerson, +11 authors E. Freeman Medicine A 3-cm oval plaque with peripheral scale, larger, MeSH -. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. government site. Herein, we are reporting a unique. sharing sensitive information, make sure youre on a federal Published by Wolters Kluwer Health, Inc. It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. It said blood spots under the skin might also be present, either as spots or dots or on larger areas. eCollection 2022. Conflicts of Interests: The authors declare there are no competing interests. (a) Patient 1: Thin, Histopathological findings of pityriasis rosealike, Histopathological findings of pityriasis rosealike eruption in patient 1. Front. Similar to other viral outbreaks, people can experience flu-like symptoms like a fever, aches, or a runny nose when the herald patch shows up, Lam says, though I was lucky enough to skip that step. In: Jameson J, Fauci AS, Kasper DL, et al., eds. Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study. 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. The site is secure. Bethesda, MD 20894, Web Policies Pityriasis rosea-like eruption revealing COVID-19. While you don't need to treat the rash, some patients ask for treatment to take care of the following. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. COVID-19 Skin Manifestation Heterogeneity - MedicineNet Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea.