are there any meds that might be good alternatives to suramin? [11], The synthesis of suramin itself and structural analogs is by successive formation of the amide bonds from their corresponding amine (aniline) and carboxyl (as acyl chloride) components. Of-course its going to react. . The chemical structure of suramin was kept secret by Bayer for commercial and strategic reasons, but it was elucidated and published in 1924 by Ernest Fourneau and his team at the Pasteur Institute. Today, 100 years later, it is being studied for a variety of applications and treatments . All rights reserved / Site by, Post-treatment Lyme disease syndrome (PTLDS), Post-coccidiomycosis (Valley fever) chronic fatigue syndrome, Treatment-Resistant Major Depressive Disorder with suicidal ideation, NARP, Leigh, and other Primary Mitochondrial Diseases, Post-chemotherapy cognitive impairment, fragility, and accelerated aging symptoms, Chronic pain syndromes in children and adults, Drug addiction recovery therapy, e.g., opioid addiction with hyperkatifeia, Treatment-resistant, post-COVID long-haulers with multisystem chronic fatigue syndrome, Severe Obsessive-Compulsive Disorder (OCD), Pediatric acute-onset neuropsychiatric syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), As an additive in organ transplant media to improve organ survival, and decrease inflammation and rejection, Subacute-chronic traumatic brain injury (TBI), Postural orthostatic tachycardia syndrome (POTS)/Dysautonomia. and turpentine with sugar taken in a very small dose attracts viral loads to the sugar and the turpentine kills the viral load. Thank you! ". ! ME/CFS is a multi-systemic neurological disease, distinct from chronic fatigue as a symptom. You can inoculate the tiniest amount of Suramin and reverse Autism! Pine needle tea, wild-foraged in the USA, picked from northern white pines | Protects against infection, strengthens immunity, high in antioxidants, natural suramin (20 Count (Pack of 1)) BALANCE PICK Natural Pine Needle Tea Powder - Product of Korea - (3.52oz (100g)) [2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. "Antimicrobial activity of the essential oil of young pine shoots (Picea abies L.)." 20. And while parents can't yet turn to their doctors to ask for this . Consult your own doctor. Ive currently run out of it but once I source a good organic variety somewhere, Im going to infuse it and make up a batch of tea to store in the fridge can then drink it anytime without having to go through the process of making it. P2X receptors are sensitized by extracellular pH, the most extreme example being the P2X2 subtype where responses to ATP are potentiated under acidic conditions and inhibited under alkaline conditions; pH changes as small as 0.03 units affect the size of the responses (153). Zoltner, Martin, Gustavo D. Campagnaro, Gergana Taleva, Alana Burrell, Michela Cerone, Ka-Fai Leung, Fiona Achcar et al. It is considered a ryanodine agent . Eastern White Pine Tree Needles: A Natural Source of Anti-Infective "Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer. Funny how uridine is a p2y2 agonist and so many people take it as a nootropic. And the raw milk has special nutrients, that pasteurization kills, so it has to be raw milk to work. But for now, I have taken the route of buying Dandelion Tea from the Health Shop. These data indicate that sgp130 inhibits the LPS-induced IL-6 trans-signal and show IL-6 and its receptor are involved in maintaining sickness behavior. Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. The boys were extensively monitored in the following 6 weeks for suramin blood levels, a panel of blood chemistry, adverse effects and autism-related traits. As we know, oil and water do not mix, but this mixes the oil into the water long enough for me to have a drink. Free shipping. Betsholtz, Christer, Ann Johnsson, Carl-Henrik Heldin, and Bengt Westermark. She discusses suramin and pine needles, corruption surrounding that, and gives many more suggestions: !function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/u4"+(arguments[1].video?'. Dont forget to also check what else you need to do to build your immune system strong it will be more than worth it in the end. Just a point of clarification. It loves the cold, the colder the better. Suramin and Autism - UC San Diego Health It is illegal to import suramin for human use without FDA approval. The simplest and most common of weeds are often the very medicine we need to counteract our ill health. Roundup is not sprayed on lawns. Dr. Jennifer Danials Turpentine and sugar was a bit of a story about a Grand Mother had done for years. S U R A M I N Suramin. Herbs for Autism: A Natural Approach - Autism Parenting Magazine I was desperate, and I gave her one capsule, 150mg, of Sytrinol. No Carter, not really. current analyst for the pharmaceutical and medical device industries, **For the Full Spike Protein Protocol (including. The Eastern White Pine (. We are doing this on a trial period to see if this interests our audience. Green tea research shows an amelioration of behavioral aberrations by a daily intake dose of the extract; doses range from 75 to 300 mg/kg after postnatal day 14 up to day 40 in animals with . "Antiproliferative effects of suramin on lymphoid cells." THE CONTENT ON THIS SITE IS PRESENTED IN SUMMARY FORM, IS GENERAL IN NATURE, AND IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY; IT IS NOT ADVICE, NOR SHOULD IT BE TREATED AS SUCH. Suramin is not approved for any use in humans in the United States except to handle the few cases of African sleeping sickness (trypanosomiasis) that have recently traveled from Africa. It also has an, Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. Naviaux, R.K. & Nguyen, K.V. It is a growth factor antagonist for palliative treatment in hormone-refractory prostate cancer and hormone-responsive metastatic prostate cancer.. Purpose. Jason Shurka was interviewing Dr Judy Mikovits PhD., and he asked the leading question: Do you know of any way, to heal oneself from the injuries from the current injection? I dont ever recommend any products that I do not believe is 100% beneficial to my clients. Quercetin. Suramin is, after all, derived from pine needle oil. More Powerful Immune System Boosters By Using Essential Oils! By facilitating the exit from the arrested mitochondrial progression needed to complete the healing cycle, recovery from chronic illnesses currently considered incurable may one day be possible. 49 natural alternative to Ivermectin, due to its rapid degradation, low toxicity to mammals 16, and 50 effectiveness in controlling nematodes and ticks 17,18. Natural Protocol: This protocol may mitigate damage in those with "buyer's remorse" who've been injected with spike protein, graphene oxide, SM-102, and mRNA.The same protocol is very useful to protect those concerned with the spike protein transmission FROM those who've been injected.. bioRxiv preprint. Suramin | Encyclopedia.com Suramin: an anticancer drug with a unique mechanism of action [2], It is unknown whether it is safe for the baby when a woman takes it while breastfeeding. As an easily accessible and low-cost natural source, they are 3! Due to its anti-inflammatory properties, turmericspecifically curcumin, the main active ingredientmay be one of the top natural remedies showing promise for treatment and management of autism symptoms. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States. We are covering everything from vaccines, parenting topics, alternative medicine, and I just gave my testimony of past abortion. Two hours later, wanted to do class with me and did her toughest one, reading. so i do wonder what the one is behind Suramin. It can heal the intestinal lining in a way that other milks cannot, and then healing the leaky gut syndrome diminishes parts of autism. Many dont want to allow their bubble to burst as they feel so safe and secure tucked away inside there. Give it a shake and there you have it, another nice bottle of Fennel water! By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Suramin sodium (suramin) dosing, indications, interactions - Medscape Suramin A New Wonder Drug For Autism? - All Natural Advantage Though, the other day I did hear someone saying that the bark is even more powerful than the needles so maybe thats something you can follow through on. Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. Other rare systemic effects include decreased blood pressure, fever, rapid heart rate, and convulsions. For a better experience, please enable JavaScript in your browser before proceeding. 100 Years of Suramin | Pine Needle Tea Shop Before you begin treatment with this medicine . $18.50. But of-course they would keep that completely secret and only use it for anyone of their own people who somehow was subjected to the j/a/b. I always come back to the analogy of a car. Yin, W. et al. A lawn treated with Roundup would also have no grass, as well as no dandelions, no anything. (2014). Frontiers | In Silico Discovery of Plant-Origin Natural Product "Antiproliferative effects of suramin on lymphoid cells. the inhibitory effects of NhPV and Suramin were confirmed by the wild type SARS-CoV-2 (hCoV-19 . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143661/, https://news.ycombinator.com/item?id=14458230. Potential Suramin Alternatives - Sytrinol and Kudzu (Anti Purinergic Therapy) Thread starter Jesse2233; . . Create an account to follow your favorite communities and start taking part in conversations. (2020). "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 M). Nos gustara mantener en contacto! a cup and enjoy! Happy researching. FDA proposes ban on curcumin and other naturopathic favorites in Suramin is 20 or more times as powerful as remdesivir, which is the only currently approved anti-COVID-19 drug. With new variants of SARS-CoV-2 emerging, the COVID-19 pandemic is . All parts of the dandelion are edible. Before you begin treatment with suramin, you and your doctor should . The active ingredients in wormwood are toxic to most types of intestinal worms, including Giardia lamblia, a parasite responsible for giardiasis. Quercetin is an antioxidant found naturally in . Antiviral research 7, no. Journal of cellular physiology 132, no. Jaw dropping information on all food and the bodies response including learning difficulties. 19. Im so thankful that we are entering into a whole new era. (especially on purinergic signaling.) 8. Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin. Suramin inhibits chikungunya virus replication through multiple mechanisms. Did it excellently as well. https://www.bitchute.com/video/fRmqkRbuaKg6/ https://www.biorxiv.org/content/10.1101/2020.10.06.328336v1, 3. Pine needles represent a suramin natural alternative, so no great need to wonder where to get suramin. '+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble"); Rumble("play", {"video":"vh8kgv","div":"rumble_vh8kgv"}); Let food be thy medicine and medicine be thy food. ~Hippocrates, So do not fear, for I am with you; do not be dismayed, for I am your God. Suramin contains six aromatic systems four benzene rings, sandwiched by a pair of naphthalene moieties plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. I love the fact that when God created this world He knew that sickness would become part of it. It prevents the association of heteromeric G proteins and therefore the receptors guanine exchange functionality (GEF). 6. Whatever you do DO NOT use radiata pine needles, they are toxic. Would another option, in addition to purinergic antagonists, be increasing extracellular pH beyond 7, if that's even possible? (3) This study also says suramin doesn't work well on p2x4. Suramin Contained In These Unusual Foods And Spices Hmm, if it does, my father might have been on to something. Quoting from our 2017 publication,Like many intravenous drugs, when administered improperly by untrained personnel, at the wrong dose and schedule, without careful measurement of drug levels and monitoring for toxicity, suramin can cause harm. Suramin | PTPases Inhibitor | MedChemExpress Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Also, Suramin not only blocks P2X7 but also the related Pannexin 1 channel. **For the Full Spike Protein Protocol (including NAC)to protect from transmission from the V and to help those who took the V,go here. And I get the best of both worlds. I am not a total fan of the taste but absolutely love the aroma of it before the water hits it. 17 (1987): 4694-4698. Stresses of all kinds are translated by the cell into graded eATP release. Maca Root 8050mg Per Caps, 4 Months' Supply Supports Reproductive Health Natural. I have others mentioned in this post: (This page contains a link to products for purchase. The same protocol is very useful to protect those concerned with the spike protein transmission FROM those whove been injected. The Trail from Suramin to Pine Needle Tea "Suramin provides an antidote for those affected by the spike protein "contagion". Bumping this to see if anyone's benefited from high dose Kudzu, Good question, I don't have a good answer, though someone with more scientific knowledge than me could probably calculate it using the paper cited above, I'd be remiss if I didn't post this Kudzu precaution literature. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Suramin further decreases the activities of a large number of enzymes involved in DNA and RNA synthesis and modification: DNA polymerases (103, 104), RNA polymerases (103, 105, 106), reverse transcriptase (18, 103), telomerase (67), and enzymes involved in winding/ unwinding of DNA (107, 108) are inhibited by suramin, as well as histone- and chromatin-modifying enzymes like chromobox proteins . Having its feet covered in snow suits it just fine. Nothing I say on this blog is intended to treat or prevent disease. Some batches of suramin contain impurities that are brown in color. (2020). Are there any supplements or lifestyle factors we can utilize to emulate the effects that suramin has? Its a 100 year old essential medicine, a WHO essential medicine for African Sleeping Sickness. National Center for Biotechnology Information. Hi, thanks for this information. UC San Diego Health, May 26, 2017, "Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy", "Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial", "Q and A - Suramin and Autism | UC San Diego Health", "Suramin is an active site-directed, reversible, and tight-binding inhibitor of protein-tyrosine phosphatases", https://en.wikipedia.org/w/index.php?title=Suramin&oldid=1126333005, Antrypol, 309 Fourneau, Bayer 205, others, This page was last edited on 8 December 2022, at 20:02. Acta Biomater 84, 378-390. [10] Other skin reactions include skin rash, swelling and stinging sensation. "Understanding the mechanism of the antimitogenic activity of suramin. Do you have any sense of whether the pine needles are higher than the others in suramin? One day I just may try that. Cells were cultured in the presence of suramin for either0h(top)or72h (bottom). NAC (N-acetyl cysteine) accelerates detoxification and is . Upon treatment with suramin, median individual glycosome volume increased from 0.0113 to 0.0127 m3 (p 0.037). As a fair amount can cling to the bottle, the next time I refill it I only add water. i just emailed a well known ME/CFS doctor i know (who wishes to remain anonymous) with the names of the two herbs/supplements mentioned at the top of this thread, and he said: "I have talked with every prominent herbalist I know to see if there is a similar substance out there, and so far, nothing.". 22. I was reading just yesterday about the Douglas Fir pine tree. Century-old drug may help children with autism symptoms: study By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. In conjunction with P2X7 that's the main pathway for leaked eATP. Here he talks about suramin, which Dr Judy mentioned. Mayan's Secret Organic Black Cumin Seed Oil. [9], It has been used in the treatment of river blindness (onchocerciasis). The autistic boys were randomized to receive either one intravenous infusion of low-dose suramin or a placebo infusion. Check with your physician if you . [1] Specifically, it is used for treatment of first-stage African trypanosomiasis caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense without involvement of central nervous system. What a super easy way to give my body Suramin on a regular basis. No I am not sure if they need to be heated for the Suramin to be released. I have been taking Sytrinol, 150 mg x 2 daily, for well over 6 months. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. For more information, please see our FAQ. by Kim Molisani January 2, 2022. On September 5th, the FDA issued a proposed rule rejecting eleven substances nominated by the American Association of Naturopathic Physicians (AANP) and like-minded organizations for use in drug compounding, including curcumin and cesium chloride. northwestern Africa and North America, is known . Low-dose PAX-101 improves autism spectrum disorder symptoms in - Healio Do you think that Rheum Palmatum is the richest plant? Personally, 40mg of Emodin a day for the past three weeks has not produced great results. Further development of suramin was passed from Dr. Naviauxs university research lab to the private sector. The mark of the evil one is this: when people sell their souls to the devil by participating in ghastly human and ch/ild sa/crifice so they can obtain more power, finances and fame. The 4 Best Natural Antihistamines - Healthline Research is already being hurriedly done in that direction in the hope that many lives can be saved and much severe illness avoided. As you dig really deep, you may be surprised what youll dig up. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes." Douglas fir is ok, white pine is ok. Hi Marilyn Suramin is a polysulfonated naphthylamine that is a primary agent in the treatment of African trypanosomiasis (African sleeping sickness) caused by Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense. Some Amish farms sell and ship this. 6 Natural Alternatives to Ivermectin & How to Use Them It loves the cold, the colder the better. Suramin is manmade and is not a natural product found anywhere in Nature. . We were lucky that suramin is a non-selective inhibitor of most of the known types of purinergic receptors. New antipurinergic drugs (antagonists) and propurinergic drugs (agonists) are now being synthesized and tested but few have yet completed Phase 3 clinical trials and been approved. Korean Journal of Veterinary Research 33, no. 6 (1992): 2166-2174. In summary, a lowered pHe enhanced the activity of all agonists at P2X2 receptors but, with the exception of suramin, not antagonists. Dr. Naviaux no longer has any control over the next clinical studies or the priorities of different diseases for testing, although he is recommending ASD, ME/CFS, post-acute SARS-CoV-2 multi-system chronic fatigue syndrome, also called long-COVID, and post-treatment Lyme disease (PTLDS) as a few of the top candidates. i wish i could grasp what this means, as it states both suramin and plavix in one study. Suramin as medication is used to treat African sleeping sickness and river blindness. i'm not sure why i'm saying that med, but for some reason it came up in my research around suramin alternatives. anyone with more of a brain than me have any ideas? The synthesis of suramin was an extension of Paul Ehrlichs pioneering work that showed that certain chemical dyes were concentrated in microbial parasites like the trypanosomes that cause African sleeping sickness. When I had an organic yard full of dandelion flowers I would harvest the flowers every morning, saut them and cook them into my scrambled eggs. There was some discussion on Phoenix rising about alternatives but it all got a bit confusing for me. y puede cancelar su suscripcin en cualquier momento. The all natural form of suramin might be licorice root, NAC,vitamin C , green tea.
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